摘要 |
N-Acyl derivatives and phosphorus-containing N-acyl derivatives of the antibiotic thienamycin of the general formula (II) <IMAGE> in which R<1> and R<2>, independently of each other, are selected from hydrogen, acyl and phosphorus-containing acyl, with the proviso that R<1> and R<2> are not both hydrogen and that, when R<1> or R<2> denotes acetyl, R<2> or R<1> is different from hydrogen and their non-toxic, pharmaceutically acceptable salts, are obtained by treating thienamycin with an appropriate acylating agent and converting the resulting compounds of the formula (II), where appropriate, into their non-toxic, pharmaceutically acceptable salts. The compounds which are obtained, and their pharmaceutically acceptable salts, are suitable for use as antibiotics. |