发明名称 TIENAMYCINDERIVAT
摘要 N-Acyl derivatives and phosphorus-containing N-acyl derivatives of the antibiotic thienamycin of the general formula (II) <IMAGE> in which R<1> and R<2>, independently of each other, are selected from hydrogen, acyl and phosphorus-containing acyl, with the proviso that R<1> and R<2> are not both hydrogen and that, when R<1> or R<2> denotes acetyl, R<2> or R<1> is different from hydrogen and their non-toxic, pharmaceutically acceptable salts, are obtained by treating thienamycin with an appropriate acylating agent and converting the resulting compounds of the formula (II), where appropriate, into their non-toxic, pharmaceutically acceptable salts. The compounds which are obtained, and their pharmaceutically acceptable salts, are suitable for use as antibiotics.
申请公布号 SE7612960(L) 申请公布日期 1977.05.22
申请号 SE19760012960 申请日期 1976.11.19
申请人 MERCK & CO INC 发明人 BARASH L;CHRISTENSEN B G;LEANZA W J;HANNAH J;SHIH D H-M
分类号 C07D477/00;A61K31/397;A61K31/40;A61K31/41;A61K31/415;A61K31/42;A61K31/425;A61K31/44;A61K31/495;A61K31/505;A61K31/655;A61K31/675;A61P31/04;C07D205/08;C07D477/20;C07D487/04;C07D498/04;C07F9/568;C07F9/6561;(IPC1-7):C07D487/04 主分类号 C07D477/00
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