发明名称 |
Fremgangsmåde til fremstilling af 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamid og syntetiske mellemprodukter deraf |
摘要 |
A process for the preparation in high yields and purity of the compound 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described. |
申请公布号 |
DK2641897(T3) |
申请公布日期 |
2016.10.03 |
申请号 |
DK20130172499T |
申请日期 |
2010.03.11 |
申请人 |
Clovis Oncology Italy S.r.l. |
发明人 |
Spinelli, Silvano;Livi, Valeria |
分类号 |
C07C271/24;C07C217/44;C07D215/22 |
主分类号 |
C07C271/24 |
代理机构 |
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代理人 |
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地址 |
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