| 摘要 |
<p>Novel process for the preparation of 1-(3,5-dihydroxyphenyl)-1-hydroxy-2-[1-methyl-2-(4-hydroxyphenyl)-ethy l-aminoethane of the formula I <IMAGE> if appropriate in the form of the diastereomers, and of the corresponding acid addition salts, in which a compound of the formula II <IMAGE> in which R1 denotes an optionally substituted arylmethyl radical; and R2 denotes hydrogen or an optionally substituted arylmethyl radical, is reduced with sodium borohydride, and the protective groups are eliminated from the resulting reaction product. Resolution to give the diastereomeric pairs of antipodes can be effected before or after elimination of the protective groups. Compared with the known processes, the novel process is distinguished by the simplicity of the procedure, surprisingly high yields and the purity of the end product.</p> |
