发明名称 |
NOVEL PYRIDINONES AND PYRIDAZINONES |
摘要 |
THIS APPLICATION DISCLOSES 5-PHENYL-1H-PYRIDIN-2-ONE AND 6-PHENYL-2H-PYRIDAZIN-3-ONE DERIVATIVES ACCORDING TO GENERIC FORMULAE I-III: WHEREIN, VARIABLES R, X, Y1, Y2, Y3, Y4, N AND M ARE DEFINED AS DESCRIBED HEREIN, WHICH INHIBIT BTK. THE COMPOUNDS DISCLOSED HEREIN ARE USEFUL TO MODULATE THE ACTIVITY OF BTK AND TREAT DISEASES ASSOCIATED WITH EXCESSIVE BTK ACTIVITY. THE COMPOUNDS ARE FURTHER USEFUL TO TREAT INFLAMMATORY AND AUTO IMMUNE DISEASES ASSOCIATED WITH ABERRANT B-CELL PROLIFERATION SUCH AS RHEUMATOID ARTHRITIS. ALSO DISCLOSED ARE COMPOSITIONS CONTAINING COMPOUNDS OF FORMULAE I-III AND AT LEAST ONE CARRIER, DILUENT OR EXCIPIENT. (NO SUITABLE |
申请公布号 |
MY158411(A) |
申请公布日期 |
2016.10.14 |
申请号 |
MY2010PI03693 |
申请日期 |
2009.01.27 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
DEWDNEY, NOLAN JAMES;TAYGERLY, JOSHUA PAUL GERGELY;KENNEDY-SMITH, JOSHUA;KONDRU, RAMA K.;LOE, BRADLEY E.;LOU, YAN;MCINTOSH, JOEL;OWENS, TIMOTHY D.;SOTH, MICHAEL;SWEENEY, ZACHARY KEVIN |
分类号 |
C07D401/10 |
主分类号 |
C07D401/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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