| 摘要 |
Hydantoins and N-alkylhydantoins of formula (I) (I) Wherein Z is hydrogen or alkyl; one of Z1 and Z2 is represented by the group -CH2-X-X1-X2; wherein X is phenylene, -C?C-, cis or trans -CH=CH- or -CH2-CQ2- in which each Q is independently selected from hydrogen and alkyl or the two Q's together form an alkylene radical having four, five or six carbon atoms; X1 is a covalent bond or a straight or branched alkylene chain having 1 to 6 carbon atoms optionally having one of its methylene groups replaced by oxa (-O-) provided that at least one carbon atom separates the oxa group from a -C?C-, -CH=CH- or -CO- group; and X2 is selected from 5-tetrazolyl, carboxyl, carbamoyl, hydroxymethyl and alkoxycarbonyl; and the other of Z1 and Z2 is represented by the group -Y-Y1-Y2-Y3; wherein Y is -CR2-CH2- in which each R is independently selected from hydrogen and methyl; Y1 is carbonyl, methylene, methylene substituted by hydroxy or methylene substituted by hydroxy and alkyl; Y is a covalent bond or a straight or branched alkylene having 1 to 7 carbon atoms, unsubstituted or substituted on the carbon adjacent Y1 by one or two groups independently selected from alkyl, bicycloalkyl and cycloalkyl; Y is hydrogen, hydroxy, alkoxy having 1 to 7 carbon atoms, cycloalkyl, bicycloalkyl, phenyl, benzyl, phenoxy or benzyloxy, wherein each of phenyl, benzyl, phenoxy and benzyloxy is unsubstituted or substituted in the benzene ring by one or more groups selected from hydroxy, halo, nitro, amino, acylamino, alkenyl, alkoxy, phenyl and alkyl which may itself be substituted by one or more halo groups; or Y is a bond, -CH2- or -CH2-CH2- and Y1, Y2 and Y taken together form a cycloalkyl group substituted by a hydroxy group, and salts thereof; have biological properties related to those of natural occurring prostaglandins and may be used in medicine, for example, in the treatment of thrombosis. |
