SECRETED AP2 AND METHODS FOR INHIBITING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide methods for alleviating symptoms of clinical disorders characterized by aberrant increase of circulating aP2 (Adipocyte protein2).SOLUTION: A method of reducing a symptom of a clinical disorder characterized by aberrantly elevated circulating aP2 administers to a subject an inhibitor of secreted aP2, secretion of aP2, or a serum aP2 blocking agent being an inhibitor of aP2. For example, glucose intolerance is reduced following administration of such an aP2 inhibitor or agent. Exemplary compositions inhibit cellular secretion of aP2 or bind to circulating aP2, thereby reducing the level or activity of aP2 in blood or serum.SELECTED DRAWING: None