Hexon isolated from simian adenovirus serotype 19, hypervariable region thereof and chimeric adenovirus using the same

摘要

Novel hexon isolated from simian adenovirus serotype 19 encoded in the polynucleotide defined as SEQ ID NO: 3, hepervariable region thereof, chimeric adenovirus comprising the same, and therapeutic use thereof provides a solution to the problem of safety and effective systemic treatment for developing gene therapeutic agents using adenovirus.

主权项

1. A chimeric adenovirus comprising a nucleic acid sequence of a first serotype adenovirus and a nucleic acid sequence of a second serotype adenovirus, said first serotype being different from said second serotype, wherein the nucleic acid sequence of the first serotype adenovirus lacks the hexon encoding sequence and comprises the nucleic acid sequence of the second serotype adenovirus which encodes the amino acid sequence of SEQ ID NO: 16.