| 发明名称 | Production of proteins in filamentous fungi | ||
| 摘要 | The present invention relates to a method for genetically modifying a filamentous fungus host for improved protein production. The method comprises that a filamentous fungus host is genetically modified to be deficient or to overexpress specific genes. The invention relates also to the modified hosts. Furthermore, the invention relates to a method for improved production or for producing an improved composition of proteins, such as cellulases, hemicellulases, other proteins involved in the degradation of lignocellulosic material, or other proteins, in a filamentous fungus host. | ||
| 申请公布号 | US9499826(B2) | 申请公布日期 | 2016.11.22 |
| 申请号 | US201113701933 | 申请日期 | 2011.05.30 |
| 申请人 | TEKNOLOGIAN TUTKIMUSKESKUS VTT | 发明人 | Pakula Tiina;Saloheimo Markku;Hakkinen Mari;Westerholm-Parvinen Ann;Penttila Merja;Vitikainen Marika |
| 分类号 | C12P21/02;C12N15/80;C07K14/37;C12N9/42;C12N9/24;C12P1/02;C12N9/16;C12P21/00 | 主分类号 | C12P21/02 |
| 代理机构 | Berggren Inc. | 代理人 | Berggren Inc. |
| 主权项 | 1. A method to genetically modify a Trichoderma reesei host for modified protein production, said method comprising: genetically modifying the host to be deficient of, with reduced or lacking amount or activity, or to overexpress, with increased amount or activity of gene tre108381 (SEQ ID NO:1) or coding region of SEQ ID NO:1, said host being capable of increased or decreased production of cellulase, hemicellulase or a protein that is expressed under a cellulase or a hemicellulase promoter. | ||
| 地址 | Espoo FI | ||