Antigen binding constructs

摘要

The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD), diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularization, and polynucleotide sequences encoding said antigen binding constructs.

主权项

1. An antigen binding construct comprising two immunoglobulin single variable domains separated by a single heavy chain constant region of an IgG or IgA antibody comprising one or more CH1, CH2, and CH3 constant region antibody domains, wherein each immunoglobulin single variable domain is capable of binding to VEGF and further wherein the first immunoglobulin single variable domain is attached to the N-terminus of the single heavy chain constant region and comprises the CDR sequences of SEQ ID NOs: 114, 115, and 116, and the second immunoglobulin single variable domain is attached to the C-terminus of the single heavy chain constant region and comprises the CDR sequences of SEQ ID NOs: 117, 118, and 119.