发明名称 4-AMINOMETHYL-1-(3,3,3-TRIARYLPROPYL)-4-ARYLPIPERIDINE AND RELATED COMPOUNDS
摘要 Compounds of the formula <IMAGE> AND THE NON-TOXIC PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF; WHEREIN Ar, Ar' and Ar'' are each phenyl, halophenyl, or alkylphenyl wherein alkyl contains from 1 to 4 carbon atoms; Ar''' is phenyl, halophenyl, alkylphenyl wherein alkyl contains from 1 to 4 carbon atoms, or pyridyl; R is hydrogen, alkyl having from 1 to 6 carbon atoms, or alkanoyl having from 1 to 6 carbon atoms; and R1 is hydrogen or alkyl having from 1 to 6 carbon atoms. These compounds are antidiarrheal agents characterized by very weak central nervous system activity.
申请公布号 ZA7802514(B) 申请公布日期 1979.06.27
申请号 ZA19780002514 申请日期 1978.05.02
申请人 GD SEARLE & CO 发明人 ADELSTEIN G
分类号 C07D211/26;C07D211/64;C07D401/06 主分类号 C07D211/26
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