发明名称 |
GENMODIFICEREDE MUS OG INDPODNING |
摘要 |
A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mII2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/II2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e.g., a myeloid leukemia or a yeloproliferative neoplasia. |
申请公布号 |
DK2485583(T3) |
申请公布日期 |
2016.10.03 |
申请号 |
DK20100822486T |
申请日期 |
2010.10.04 |
申请人 |
REGENERON PHARMACEUTICALS, INC.;Institute for Research in Biomedicine (IRB);Yale University |
发明人 |
RONGVAUX, Anthony;STEVENS, Sean;Murphy, Andrew J.;Flavell, Richard;EYNON, Elizabeth;GALAN, Jorge;WILLINGER, Tim;MANZ, Markus, G.;YANCOPOULOS, George D. |
分类号 |
A01K67/027;A61K49/00;C07K14/52;C07K14/535;C07K14/54;C07K14/715;C12N9/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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