Component preparation system

摘要

Disclosed herein are centrifuge-free self-contained systems for aseptically separating components of whole blood comprising at least one cassette for receiving whole blood; at least one red blood cell exclusion filter; at least one leukocyte reduction filters; at least one platelet exclusion filter; a plurality of product cassettes; and optionally a plurality of pumps and valves; and wherein the filters, pumps, valves, and cassettes are fluidly connected by tubing and the system does not include a centrifuge. Also disclosed are methods for obtaining blood components using the system.

主权项

1. A centrifuge-free self-contained system for aseptically separating components of whole blood comprising:
a cassette for receiving whole blood; at least one red blood cell exclusion filter; at least one leukocyte reduction filter; at least one platelet exclusion filter; a plurality of product cassettes; wherein the filters and cassettes are fluidly connected by tubing and the system does not include a centrifuge; and wherein the system comprises a flow route wherein the cassette for receiving whole blood is fluidly connected to the leukocyte-reduction filter; the leukocyte-reduction filter is fluidly connected to at least one platelet exclusion filter in series; the platelet exclusion filter is fluidly connected to a leukocyte-reduced red blood cell reservoir cassette; the leukocyte-reduced red blood cell reservoir cassette is fluidly connected to a first gate; the first gate is fluidly connected to a pump; the pump is fluidly connected to a red blood cell exclusion filter; the red blood cell exclusion filter is fluidly connected to a second gate; and the second gate is fluidly connected to the leukocyte-reduced red blood cell reservoir cassette.