| 发明名称 |
Immunogenic composition of killed leptospira bacteria |
| 摘要 |
The present invention pertains to a composition containing an immunogenic cell preparation of killed Leptospira bacteria in an ethylenediaminetetraacetic acid solution. The invention also pertains to a vaccine to protect an animal against an infection with leptospira bacteria, wherein the vaccine comprises this composition. Also, the invention pertains to the use of ethylenediaminetetraacetic acid to stabilize an immunogenic preparation of killed Leptospira bacteria in a liquid carrier, by dissolving the ethylenediaminetetraacetic acid in the carrier. |
| 申请公布号 |
US9480734(B2) |
申请公布日期 |
2016.11.01 |
| 申请号 |
US201314420946 |
申请日期 |
2013.08.16 |
| 申请人 |
Intervet Inc. |
发明人 |
Klaasen Henricus Leo Bernardus Maria;Rijke Eric Onno |
| 分类号 |
A61K39/02;A61K47/18;A61K39/00 |
主分类号 |
A61K39/02 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising an immunogenic cell preparation of killed whole cell Leptospira bacteria and 5 to 50 mmols of ethylenediaminetetraacetic acid (EDTA) per liter solution; wherein the killed whole cell Leptospira bacteria are Leptospira interrogans serogroup Australis serovar Bratislava. |
| 地址 |
Madison NJ US |
