| 摘要 |
<p>Compounds of the formula <IMAGE> in which each R is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, hydroxy, cyano, or halo, and both R groups are identical and are symmetrically located; R1 is C1-C3 alkyl and R2 is methyl, or R1 and R2 taken together are (CH2-n in which n is an integer from 4 to 6; and (1) Xc and Xd are hydrogen, and the combination of Xa and Ya and of Xb and Yb each represents a double bond, subject to the limitation that, when R1 is C1-C3 alkyl and is other than methyl, Xc, Xd, and R1 are all in an alpha -configuration; or (2) Xa, Xb, Xc, Xd, Ya, and Yb are hydrogen, subject to the limitation that both Xc and Xd are in an alpha -configuration, both Xa and Xb are in an alpha -configuration or in a beta -configuration, and, R1, when it is C1-C3 alkyl, is in an alpha -configuration, are useful in inhibiting the action of androgens or are intermediates to such anti-androgen compounds.</p> |
