| 摘要 |
Title compds. (I; R1 = H, lower alky1, Ph; R2 = H, Cl, MeO; R3 H, MeO or forming MeO2 bonded together R2; R4, R5 = H, lower alky1; R6 = H, lower alky1; R7 = lower alkoxy or forming MeO2 or EtO2 bonded together R6; X = carbony1, sulfony1; n = 2,3), useful as heart rate decreasing agent were prepd. by reaction of II and III. Thus, 3-[N-(5,6-dimethoxy)-phthalimidine -propionaldehyde-diethylacetal and 3,4-dimethoxy-pheny1-methylamine in EtOHwere reduced with H2, using Pd/C(10%), and treated with HCl to give 5,6-dimethoxy-2N-(3-[2-(3,4-dimethoxy)-phenylethylamino -propy1)-phtalimidine-HCl.
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