Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections

摘要

This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.

主权项

1. A vaccine composition comprising:
an adjuvant formulation; and an effective amount of FimCH or truncated FimH,wherein the adjuvant formulation comprises the compound of formula (I)or other pharmaceutically acceptable saltand a buffer of citrate or succinate from 15 mM to about 50 mM.