发明名称 |
COMPOSITIONS COMPRISING ADAMTS13 FOR USE IN METHODS FOR THE RECANALIZATION OF OCCLUDED BLOOD VESSELS IN AN INFARCTION |
摘要 |
Provided herein are methods for recanalization of occluded blood vessels in a subject having an infarction. The method includes a step of administering to the subject a therapeutically effective amount of isolated ADAMTS13 protein at particular dosages and ranges of times after detection of the infarction. As described herein, ADAMTS13 advantageously recanalizes occluded blood vessels and reduces infarction size, even when administered a prolonged period after stable occlusion. Accordingly, such methods and compositions are useful for the treatment of infractions caused by blood vessel occlusion. |
申请公布号 |
WO2016191565(A1) |
申请公布日期 |
2016.12.01 |
申请号 |
WO2016US34353 |
申请日期 |
2016.05.26 |
申请人 |
BAXALTA INCORPORATED;BAXALTA GMBH;KATHOLIEKE UNIVERSITEIT LEUVEN |
发明人 |
PLAIMAUER, Barbara;ROTTENSTEINER, Hanspeter;SCHEIFLINGER, Friedrich;DE MEYER, Simon;DENORME, Frederik |
分类号 |
A61K38/48;A61P9/10 |
主分类号 |
A61K38/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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