发明名称 |
Process for the production of pancreatin pellets |
摘要 |
Pancreatin pellets are produced by a process employing extrusion techniques. In the process, a mixture of pancreatin powder and selected solvent is formed into a pliable mass suitable for extrusion. The extrusion is conducted followed by a cutting, shaping or forming of the extruded mass into pre-pellet like forms. Further drying and mechanical working of the pre-pellet forms results in the final pancreatin pellet of improved pharmaceutical and mechanical stability. A special aspect of the process is the selection of a solvent for mixing with pancreatin powder that is harmless to enzymes. Such solvents typically include isopropanol and acetone.
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申请公布号 |
US4280971(A) |
申请公布日期 |
1981.07.28 |
申请号 |
US19790089963 |
申请日期 |
1979.10.31 |
申请人 |
KALI-CHEMIE PHARMA GMBH |
发明人 |
WISCHNIEWSKI, MARTIN;FEICHO, LUTZ;FISCHER, GERHARD;PESCHKE, GUENTER |
分类号 |
A61K9/20;A61K9/16;A61K9/50;A61K38/43;A61K38/46;A61P1/00;(IPC1-7):B22D11/01 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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