发明名称 |
FREMGANGSMAATE VED FREMSTILLING AV NYE STEROID-SPIRO-OXATHIAZOLIDINDERIVATER |
摘要 |
New steroid-spiro-oxathiazolidine derivatives pharmaceutical compositions containing the same, and to a process for the preparation thereof are disclosed. The new compounds have antimineral corticoide effects and have the following formula (I), <IMAGE> (I) wherein R1 is a C1-3 alkyl or a C2-4 alkenyl group, and Z is a group of the formulae (II) to (VI), <IMAGE> (II) <IMAGE> (III) <IMAGE> (IV) <IMAGE> (V) <IMAGE> (VI) wherein R2 is methyl or ethyl, R3 is hydrogen or methyl R4 is hydrogen, a C1-3 alkyl group, a di-(C1-4 alkyl)-amino-C1-4 alkyl group, a C2-4 alkylcarbonyl group, a C2-4 alkoxycarbonyl group or a C3-6 carboxyalkylcarbonyl group, and the dotted lines may represent additional valence bonds, with the proviso that if Z is a group of the formula (VI), a double bond exists between the carbon atoms in positions 4 and 5 or 5 and 6, and if R4 is a di-(C1-4 alkyl)-amino-C1-4 alkyl group or a C3-6 carboxyalkylcarbonyl group, the compounds may also be formed as their salts. |
申请公布号 |
NO810838(A) |
申请公布日期 |
1981.09.14 |
申请号 |
NO19810000838 |
申请日期 |
1981.03.11 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR RT., |
发明人 |
SOLYOM, SANDOR,;SZILAGYI, KATALIN,;TOLDY, LAJOS,;SCHAEFER, INGE,;SZONDY, ELEONORA,;BORVENDEG, JANOS,;HERMANN, ILONA, |
分类号 |
A61K31/58;A61P7/10;C07J41/00;C07J43/00;(IPC1-7):07J/ |
主分类号 |
A61K31/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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