| 摘要 |
<p>There is described a process for the preparation of a compound of the formula I …<??>A process for the preparation of a compound of the formula I …<CHEM>… which comprises reacting at least about 0.1 mole of triethylamine and at least about 0.1 mole of chlorotrimethylsilane per mole of 6 beta -acylaminopenicillin-1 beta -sulfoxide compound of the following formula (II) …<CHEM>… in a substantially anhydrous ether or hydrocarbon solvent, in which solvent the above 6 beta -acylaminopenicillin-1 beta -sulfoxide (II) is present in a concentration of about 0.7 molar or greater, in a substantially anhydrous atmosphere at a temperature between about -20 DEG C and about 20 DEG C where in the above formulas R1 is hydrogen or an acyl group derived from carboxylic acid; and R2 is an acyl group derived from a carboxylic acid; or R1 and R2 taken together with the nitrogen atom to which they are attached form a group of the formula</p> |
