| 发明名称 | Pharmaceutical lipid compositions | ||
| 摘要 | The present invention relates to a particulate composition containing; a) 5 to 90% of at least one phosphatidyl choline component b) 5 to 90% of at least one diacyl glycerol component, at least one tocopherol, or mixtures thereof, and c) 1 to 40% of at least one non-ionic stabilizing amphiphile, where all parts are by weight relative to the sum of the weights of a+b+c and where the composition contains particles of at least one non-lamellar phase structure or forms particles of at least one non-lamellar phase structure when contacted with an aqueous fluid. The invention additionally relates to pharmaceutical formulations containing such compositions, methods for their formation and methods of treatment comprising their administration. | ||
| 申请公布号 | US9526788(B2) | 申请公布日期 | 2016.12.27 |
| 申请号 | US201514715757 | 申请日期 | 2015.05.19 |
| 申请人 | CAMURUS AB | 发明人 | Johnsson Markus;Tiberg Fredrik |
| 分类号 | A61K9/48;A61K47/24;A61K9/127;A61K31/05;A61K38/22;A61K38/26;A61K38/28;A61K38/31 | 主分类号 | A61K9/48 |
| 代理机构 | J.A. Lindeman & Co., PLLC | 代理人 | J.A. Lindeman & Co., PLLC |
| 主权项 | 1. A composition comprising; a) 5 to 50% of at least one phosphatidyl choline component; b) 5 to 90% of at least one diacyl glycerol component, at least one tocopherol, or mixtures thereof; c) 1 to 10% of at least one non-ionic amphiphile consisting essentially of surfactants having a molecular weight below 8,000 amu; a co-solvent; and an active agent;wherein all parts are by weight relative to the sum of the weights of a+b+c and wherein the composition forms particles of at least one non-lamellar phase structure when contacted with an aqueous fluid. | ||
| 地址 | SE | ||