| 摘要 |
Title compds. I (R = -NR1(CH2)nCOOR2, -NR3CH(R4)-(CH2)m-COOR5; R1 = C2-10 alkyl, C3-10 alkenyl, alkynyl, C2-10 alkoxy alkyl; R2,R5 = H, C1-10 alkyl, C6-10 aryl, C7-12 aralkyl; n = 1. 2. 3; R3 = H, Me; R4 = C1-10 alkyl, substituted Ph, Bz; n = 0, 1, 2, Ar = substituted Ph, naphthyl furanyl, tetrahydronaphthyl, 1,2-ethylenedioxyphenyl, etc.), useful as thrombin inhibitors, were prepd. by the reaction of N2-arylsulfonyl-L-arginyl halide II(X = halo) and amino acid derivatives (III). Thus, N2-(2-dibenzophenyl sulfonyl)-L-arginyl-N-butyl glycine was prepd. by using L-arginine and 2-dibenzo thiophene sulfonyl chloride as starting materials.
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