NOVEL COMPOUNDS FOR REGENERATION OF TERMINALLY-DIFFERENTIATED CELLS AND TISSUES

摘要

The present invention discloses novel compounds and their use in medicine. Preferably the compounds are applicable in the therapy of disorders associated with damaged post-mitotic tissues in mammals. The novel compounds are compounds according to formula I (I) wherein—X is O (oxygen) or S (sulphur),—R1 is a substituent selected from the group consisting of straight-chain (unbranched) or branched, unsubstituted or substituted alkyl groups, cycloalkyl groups, alkylcycloalkyl groups, aryl groups, alkylaryl groups, arylalkyl groups, cycloalkylaryl groups and arylcycloalkyl groups, which optionally contain heteroatoms,—R2 is a substituent selected from the group consisting of straight-chain (unbranched) or branched, unsubstituted or substituted C1-C6 alkyl groups, C1-C6 alkoxy groups, C1-C6 alkoxy alkyl groups and C2-C6 alkenyl groups,—R3 is a substituent selected from the group consisting of straight-chain (unbranched) or branched, unsubstituted or substituted alkyl groups, cycloalkyl groups, alkylcycloalkyl groups, aryl groups, alkylaryl groups, arylalkyl groups, cycloalkylaryl groups and arylcycloalkyl groups, which optionally contain heteroatoms,—or a stereoisomer, a tautomer, a prodrug or a pharmaceutically acceptable salt thereof.;

主权项

1. A compound of formula I wherein X is O (oxygen) or S (sulphur), R1 is a substituent selected from the group consisting of straight-chain (un-branched) or branched, unsubstituted or substituted alkyl groups, cycloalkyl groups, alkylcycloalkyl groups, aryl groups, alkylaryl groups, arylalkyl groups, cycloalkylaryl groups and arylcycloalkyl groups, which optionally contain heteroatoms, R2 is a substituent selected from the group consisting of straight-chain (unbranched) or branched, unsubstituted or substituted C1-C6 alkyl groups, C1-C6 alkoxy groups, C1-C6 alkoxy alkyl groups and C2-C6 alkenyl groups, R3 is a substituent selected from the group consisting of straight-chain (unbranched) or branched, unsubstituted or substituted alkyl groups, cycloalkyl groups, alkylcycloalkyl groups, aryl groups, alkylaryl groups, arylalkyl groups, cycloalkylaryl groups and arylcycloalkyl groups, which optionally contain heteroatoms, or a stereoisomer, a tautomer, a prodrug or a pharmaceutically acceptable salt thereof.