3-Beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation.

摘要

A process for the preparation of 3β,7β,15α-trihydroxy-5- androsten-17-one and the 3,15-dipivalate thereof comprises epimerizing 3p,7a,15a-trihydroxy-5-androsten-17-one in the presence of a ketone with or without a solvent, with dilute mineral acid and subsequent treatment with an organic base, and optionally subsequently esterifying the 3p- and 15a-positions of the resultant 3β,7β,15α-triol with a reactive derivative of pivalic acid.