| 摘要 |
<p>Lithium salts of formula R-NH-CO-P(=O)-(OLi)2 (I) and their pharmaceutically-acceptable salts are new (where R is opt. branched alkyl, esp. CH3). (I) is prepd. by treating a phosphoric acid having two acid gps. blocked with an alkyl isocyanate. Blocking of the acid gps. is pref. effected using triethylamine or a basic Li deriv. LD50 of (I: R= CH3)= 3200 mg/kg (route not stated). (I) may be given orally or by injection at a unit dose of 250-750 mg. (I) have a similar effect to Li carbonate, but with a slightly superior action. They therefore cause a decrease in aggression, decrease in movement and curiosity and protection against convulsions.</p> |
