发明名称 |
Novel pentapeptides, processes for their production, pharmaceutical compositions comprising said pentapeptides and their use |
摘要 |
Pentapeptides of formula I, <IMAGE> (I) wherein Z1=H, CH3 or amidino; R1=H or alkyl and R2=H or R1+R2=-CH2-CH2-; R3=m- or p-OH or -alkoxy; B=residue of a (D)- alpha -amino acid; R4=H or alkyl; Z2=optionally substituted phenyl; and E= beta -amino alcohol residue (whereby when Z1=H or CH3, R4=C3-4-alkyl) as well as their esters and the acid addition salts and complexes of such peptides and esters. Compounds according to the invention have valuable pharmacological, in particular LH-secretion inhibiting activity.
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申请公布号 |
US4405607(A) |
申请公布日期 |
1983.09.20 |
申请号 |
US19810282045 |
申请日期 |
1981.07.10 |
申请人 |
SANDOZ LTD. |
发明人 |
CARDINAUX, FRANCOIS;HUGUENIN, RENE;PLESS, JANOS |
分类号 |
A61K38/00;C07K14/70;(IPC1-7):A61K37/00;C07C103/52 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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