| 摘要 |
Novel compounds are provided which differ in their effect from dynorphin(1-13) by neither potentiating nor antagonizing narcotics, such as morphine, in naive animals. In tolerant hosts the new compounds potentiate narcotic or peptide induced analgesia, and in addition are less susceptible to degradation than dynorphin(1-13). …<??>The compounds are amidated dynorphin(1-10) to (1-12), in which one or more amino acids, particularly AA<8> and AA<9>, may be exchanged with different amino acids. …<??>Particularly preferred of the new compounds are polypeptides having ten amino acids with nitrogen containing moieties at both termini. |
