Method of producing gamma -globulin for intravenous injection and therapeutic agent produced thereby

摘要

A method of producing gamma -globulin which can be administered intravenously without adverse reactions and loss of opsonic activity is provided. The method comprises treating gamma -globulin with pepsin or uropepsin in a neutral pH range of 6.0 to 7.5. The aggregates in gamma -globulin are selectively decomposed by the method of the present invention, while any decomposition of monomer gamma -globulin molecule is substantially prevented. A therapeutic agent for intravenous injection which is reduced its anticomplementary activity and is stabilized by adding uropepsin which serves simultaneously as a proteolytic enzyme and a stabilizer, to human gamma -globulin. Uropepsinogen can be also as a stabilizer.