发明名称 ANTI-MICROBIAL PEPTIDES AND METHOD FOR DESIGNING NOVEL ANTI-MICROBIAL PEPTIDES
摘要 Disclosed herein are novel anti-microbial peptides with inhibitory activity against M. tuberculosis and streptococcus bacteria. Additionally, a method for designing novel anti-microbial peptides is disclosed.
申请公布号 US2016376320(A1) 申请公布日期 2016.12.29
申请号 US201615259942 申请日期 2016.09.08
申请人 RENSSELAER POLYTECHNIC INSTITUTE 发明人 BELFORT Georges;PEARSON C. Seth;MURRAY Brian;KARANDE Pankaj Sakharam;KWAK Jun Ha;MCDONOUGH Kathleen A.;KLOOS Zachary Andrew
分类号 C07K7/08;G06F19/12;A01N43/38;A61K38/10;A61K45/06 主分类号 C07K7/08
代理机构 代理人
主权项 1. An isolated peptide comprising a sequence X1X2X3X4X5X6X7X8X9X10X11X12X13 (SEQ ID NO: 6), wherein X1, X2, X4, X6, and X11 are each a hydrophobic amino acid, wherein X3 is selected from the group consisting of S, T, N, and Q, wherein X5, X12, and X13 are each a cationic amino acid, wherein X7, X8, X9, and X10 are selected from the group consisting of a hydrophobic amino acid and a cationic amino acid, wherein X7 and X8 cannot both be a hydrophobic amino acid and cannot both be a cationic amino acid, and wherein X9 and X10 cannot both be a hydrophobic amino acid and cannot both be a cationic amino acid.
地址 Troy NY US