OLIGOPEPTIDES WITH SPECIFIC INHIBITING PROPERTIES OF COLLAGEN INDUCED AGGREGATION, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The invention relates to oligopeptides with specific inhibiting properties of collagen induced aggregation, process for preparing the same and pharmaceutical compositions containing them. These peptides comprise no more than 10 aminoacids containing the following sequence :… -(N-ter) A-X1-Gly-Y-Gly-X2-A (C-ter)-… in which:… X1 and X2 represent, independently from each other, either a hydroxyprolyl or a prolyl residue;… Y represents either a -Z-X3- or a -X3-Z- residue wherein X3 is a hydroxyprolyl or prolyl residue and Z is a spacer aminoacyl residue and… A is preferably a lysyl residue;… Z is preferably a glutaminyl, glutamyl, aspartyl or asparaginyl residue.