| 摘要 |
PURPOSE:The titled drug that contains at least one selected from caffeic acid, eupatilin and 4'-demethyl-eupatilin as an active ingredient, thus showing high safety and being used as a remedy for asthma, an anti-inflammatory or an immunizator. CONSTITUTION:The objective drug contains, as an active ingredient, at least one selected from caffeic acid of formula I , eupatilin of formula II and 4'-demethyleupatilin of formula III. Leucotriene which is known as a physiologically active substance and relates to prostaglandin is formed in the inflamming tissues in the lungs during asthma attack to contract muscles in the lungs and bronchi. The compounds of formula I -III selectively inhibits only the activity of 5- lipoxygenase relating to the production of leucotriene to show strong antiasthma and anti-inflammatory actions. The allergic agent can be administered orally and parenterally and has low acute toxicity of less than 200mg/kg as LD50.
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