| 摘要 |
NEW MATERIAL:A thiazole derivative shown by the formula I (A is NH2, or lower acylamino; B is pyridyl, piperidyl, lower alkyl-substituted piperidyl, 4,4- substituted piperidyl, piperazyl, pyrazyl, pyrazolyl, imidazolyl, or pyridazyl; n is 1, 2 or 3) or its acid addition salt. EXAMPLE:2-Amino-4-[2-(piperidin-1-yl)ethyl]thiomethylthiazole. USE:A gastric secretion inhibitor. PREPARATION:A compound shown by the formula II(Y is SH or group shown by the formula III) is reacted with a compound shown by the formula X-(CH2)n- B(X is halogen) to give a compound shown by the formula I . Or, a compound shown by the formula IV in the compound shown by the formula I obtained by the above-mentioned method is reacted with a lower fatty acid anhydride or lower acylhalide to give a compound shown by the formula V in the compound shown by the formula I . If necessary, the prepared base is converted into its salt.
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