| 摘要 |
PURPOSE:In a combination of components wherein at least one is solid and their blending is inhibited, a solid pharmaceutical preparation having improved stabilization effect and improved effect of each component, obtained by coating the solid component with water-soluble wax solid at normal temperature in a molten state. CONSTITUTION:In a combination of components (e.g., acidic drug and alkali drug) wherein their blending is inhibited, a solid component is coated with water- soluble wax solid at normal temperature in a molten state, to give a solid pharmaceutical preparation. Wax having solubility of >=5g in 100g water is preferable as the water-soluble wax, and 0.5-3 times as much as polyethylene glycol 2,000-6,000, polyethylene glycol, polyethylene nonylphenol ether, etc. as the solid component by weight is used. A substance (e.g., phosphoric acid, or oxalic acid) to promote stability of the solid component of inhibited blending may be added to the water-soluble wax.
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