| 摘要 |
<p>Novel biological active polypeptides, including a new class of transforming growth factor (TGF) polypeptides which exhibit cell growth promoting properties are disclosed as well as a process for isolating the TGF polypeptides from both human and murine cell lines in homogeneous form. Also disclosed are antigenic oligopeptides derived from the TGF polypeptides and antibodies raised therefrom which have application in the detection and treatment of malignancies and oligopeptides which have the ability to bind with cellular growth factor receptors and thus to interfere with transformation of certain cell lines into a cancerous state. Compositions and methods based on the disclosed peptides for detection and treatment of cancer and other proliferative diseases and for cell growth associated treatment, e.g., wound healing and ulcer therapy, are also described.</p> |
