| 摘要 |
PURPOSE:The titled pharmaceutical, obtained by incoporating a polypeptide having physiological activity such as central activating action or hormonal action, with a specific higher aliphatic compound as an absorption promoter, and capable of enhancing the percutaneous absorption of polypeptides and prolonging the drug effect without side effects. CONSTITUTION:An external pharmaceutical for percutaneous absorption obtained by incorporating a polypeptide having physiological activity, e.g. luteinzing hormone, thyrotropin-releasing hormone or vasopressin, with at least one selected from the group consisting of 5-30C aliphatic monocarboxylic acids, 10-22C monohydric alcohols, 7-17C aliphatic monoamides and 10-16C aliphatic monoamines. The higher aliphatic compound enhances the percutaneous absorption of the polypeptide based drug. Low-molecular weight polypeptide based drugs having poor absorbability through digestive tracts can be percutaneously adnimistered without using injection nor oral administration, and the drug effect can be maintained for a long period without pain nor side effect.
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