Synergistic microbicidal combinations

摘要

Antimicrobial compositions based on the synergistic combination of 2-methyl-3-isothiazolone and selected commercial microbicides where the compositions are substantially free of halogenated 3-isothiazolone, are disclosed. Particularly preferred are combinations of 2-methyl-3-isothiazolone together with benzoic acid, citric acid, sorbic acid, 1,2-dibromo-2,4-dicyanobutane, 1,3-dimethylol-5,5-dimethylhydantoin, phenoxyethanol, benzyl alcohol, zinc pyrithione or climbazole, that provide enhanced microbicidal efficacy at a combined active ingredient level lower than that of the combined individual 3-isothiazolone and commercial microbicide effective use levels.

主权项

1. A microbicidal composition consisting of 2-methyl-3-isothiazolone and benzyl alcohol which is effective for inhibiting growth of a microorganism selected from bacteria, mold or yeast, wherein either (a) the ratio of 2-methyl-3-isothiazolone to benzyl alcohol is from 1/0.27 to 1/6.7, or 1/0.13 to 1/16, and over such range the composition exhibits synergy for inhibiting growth of Candida albicans; (b) the ratio of 2-methyl-3-isothiazolone to benzyl alcohol is from 1/1 to 1/20, and over such range the composition exhibits synergy for inhibiting growth of Staphylococcus aureus; (c) the ratio of 2-methyl-3-isothiazolone to benzyl alcohol is from 1/6 to 1/600, and over such range the composition exhibits synergy for inhibiting growth of Pseudomonas aeruginosa; or (d) the ratio of 2-methyl-3-isothiazolone to benzyl alcohol is from 1/24 to 1/32, and over such range the composition exhibits synergy for inhibiting growth of Aspergillus niger.