| 主权项 |
1. An oral care composition comprising
an orally acceptable carrier, and a multilayer film, wherein the multilayer film is entrained in the orally acceptable carrier, and wherein said multilayer film comprises at least one mucoadhesive layer and one overlying layer, and wherein the mucoadhesive layer comprises:
a mucoadhesive polymer,a first polymeric base, andan odor controlling active; and wherein the overlying layer comprises:
a release modulating polymer,a second polymeric base, andoptionally a flavorant;
wherein said odor controlling active is a zinc containing compound selected from the group consisting of: zinc oxide; zinc citrate; zinc lactate; zinc chlorite; zinc chloride; zinc zeolite; and a combination of two or more thereof;wherein the mucoadhesive polymer is selected from the group consisting of a polyacrylic acid or polyacrylate, a cross-linked polyacrylic acid or polyacrylate, a polyalkyl acrylate, a cross-linked polyalkyl acrylate, polyvinylpyrrolidone, a copolymer of polyvinylpyrrolidone and polyacrylate, chitosan or a chemically-modified chitosan, and a combination of two or more thereof;wherein the release modulating polymer is polyvinyl acetate or hydroxyl ethyl cellulose;wherein either or both of the first polymeric base and second polymeric base is selected from the group consisting of: hydroxypropylmethyl cellulose; methyl cellulose; hydroxypropyl cellulose; and copolymers thereof;wherein the mucoadhesive polymer comprises from 2% to 5% by weight of the mucoadhesive layer; and wherein the multilayer film comprises from 0.1% to 5% by weight of the oral care composition. |
