发明名称 |
High performance liquid chromatography (HPLC) analysis of sulfur mustards and their decomposition by-products by derivatization |
摘要 |
A method for the simultaneous detection, separation and analysis by reverse phase HPLC of sulfur mustard type compounds and their major hydrolysis and oxidation by-products utilizes a novel precolumn enhancement derivatization procedure. The method involves the reaction of these nonchromophoric sulfides with N-halogeno-N-metal arylsulfonamidates on a microscale to produce UV or visible absorbing or fluorescing arylsulfonylsulfilimine compounds. These arylsulfonylsulfilimine derivatives can then be readily separated on a low polarity C-18 column by reverse phase HPLC. The method permits quantitation of these sulfides by UV detector response in quantities as small as 20 nanograms.
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申请公布号 |
US4565787(A) |
申请公布日期 |
1986.01.21 |
申请号 |
US19830492862 |
申请日期 |
1983.05.09 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY |
发明人 |
BOSSLE, PAUL C.;MARTIN, JOHN J.;SARVER, EMORY W.;SOMMER, HAROLD Z. |
分类号 |
G01N30/02;G01N30/06;G01N30/74;G01N33/00;(IPC1-7):G01N33/00;C07C143/78 |
主分类号 |
G01N30/02 |
代理机构 |
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