摘要 |
A process for preparing rimantadine from 1-adamantanecarbonitrile is provided. The process comprises contacting 1-adamantanecarbonitrile in an ether solvent with CH3M where M is lithium or MgX wherein X is Br or Cl, and contacting the intermediate compound with a reducing agent, such as lithium aluminum hydride or catalytic hydrogenation, to form rimantadine free base. Salts can be formed from the free base, preferably the hydrochloride salt by reaction with HCl. |