| 摘要 |
NEW MATERIAL:A compound expressed by the formula [R<1> is (protected) amino; R<2> is (protected) carboxy lower alkyl; R<3> is (protected) carboxy; R<4> is H or thiadiazolylthiomethyl]. EXAMPLE:7-[2-(4-Formylamidopyrimidin-2-yl)-2-tert-butoxycarbon-yl- methoxyimino acetamido]-3-(1,3,4-thiadiazol-2-yl)thiomet-hyl-3-cephem-4-carboxylic acid. USE:An antimicrobial agent. PREPARATION:For example, a starting material 2-(4-formamido-pyrimidin-2-yl)-2- tert-butoxycarbonylmethoxy-iminoa cetic acid is reacted with 7-amino-3-(1,3,4- thiadiazol-2-yl)thiomethyl-3-cephem-4-carb-oxylic acid in methylene chloride solvent in the presence of trimethylsilylacetamide.
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