| 摘要 |
PURPOSE:To obtain an equatorial alcohol useful mainly as drugs, agricultural chemicals, etc., in the field of so-called fine chemistry, by treating a specific reagent with a ketone and reacting the reaction product with a carbon nucleating agent at <=0 deg.C. CONSTITUTION:A compound shown by the formula I (R' is alkyl or halogen; R'' is alkyl or H) as a reagent is treated with a ketone. Then, the reaction product is reacted with a carbon nucleating agent, preferably an organolithium compound, and/or a Grignard reagent, at <=0 deg.C to give the titled compound. Cyclohexane or 4-tertiary butylcyclohexane is used as the ketone. Preferably the reaction is carried out in the presence of an organic solvent at the reaction temperature of -78 deg.C.
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