| 摘要 |
PURPOSE:To obtain a compound useful as a synthetic intermediate for coronary vasodilators in good yield, by carrying out the optical resolution of dl-isomer of a propionic acid derivative using an optically active benzylamine compound as a resolving agent. CONSTITUTION:The dl-isomer of a compound expressed by formula I (A is aryl which may be substituted by lower alkoxy; R<1> is lower alkyl) is reacted with an optically active benzylamine compound expressed by formula II (R<2> is lower alkyl; Y is phenyl which may be substituted), particularly the l-isomer to form two kinds of diastereomer salts, and the aimed substance is obtained. The compound expressed by formula II is used in an amount of 1-1.1 equivalents based on the compound expressed by formula I and isopropyl ether, etc., may be used as a solvent.
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