| 摘要 |
NEW MATERIAL:6-(2-Hydroxyphenyl)pyrimidine derivative of formula I (R1 is lower alkyl, phenyl, methylthio, amino; R2 is nitro, amino) and its acid adduct in case of R2=amino. EXAMPLE:6-(2-Hydroxyphenyl)-2,4-dimethyl-5-nitropyrimidine. USE:It has an analgesic action and is used as a medicine. PREPARATION:The reaction of 2-methyl-3-nitrochromone of formula II with an amidine of formula III is carried out, preferably at a molar ratio of 1/(2-5), in a solvent such as methanol to give a compound of formula I where R2 is NO2. Subsequently, the product is reduced to convert the group R2 into NH2.
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