| 摘要 |
NEW MATERIAL:A porphyrin derivative of formula I [R is H, (CH2CH2O)nH, n is 2-6). EXAMPLE:7,12-Bis{1-[2-(2-hydroxyethyloxy)ethyloxy]ethyl}-3,8,13,17-tet ramethyl, 2,18-bis{2-[2-(2-hydroxyethyloxy)ethyloxy]carbonylethyl}-21H,23H-porph ine. USE:It has photosensitizing action and affinity to cancer cells and is useful for diagnosis or remedy for cancer. PREPARATION:7,12-Diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18- dipropionic acid is treated with a hydrobromic acid solution in acetic acid, then allowed to react with a compound of formula II to give a porphyrin derivative of formula III. The product is hydrolyzed to give the compound of formula I.
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