发明名称 |
CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES |
摘要 |
FIELD: medicine.SUBSTANCE: group of inventions relates to a monomeric calicheamicin derivative/antibody conjugate, as well as a method for treating an individual with a proliferative disorder other than cell expression of CD22 antigen on surface thereof, comprising administering a therapeutic dose of said conjugate.EFFECT: claimed conjugate is characterised by significantly higher drug load than previously described methods with a low degree of aggregation and low conjugate fraction (LCF).32 cl, 29 dwg, 13 tbl, 9 ex |
申请公布号 |
RU2602878(C2) |
申请公布日期 |
2016.11.20 |
申请号 |
RU20110108928 |
申请日期 |
2011.03.09 |
申请人 |
UAJT KHOLDINGZ KORPOREJSHN |
发明人 |
KUNZ Artur;MORAN Dzhastin Kejt;RUBINO Dzhozef Tomas;DZHEJN Neera;VIDUNAS JUdzhin Dzhozef;SIMPSON Dzhon MakLin;ROBBINS Pol Devid;MERCHANT Nishit;DAJDZHOSEF Dzhon Fransis;RAPPEN Mark Edvard;DAMLE Nitin Krishnadzhi;POPLUELL Endrju Dzhordzh |
分类号 |
A61K39/395;A61K9/19;A61K41/00;A61K45/00;A61K47/26;A61K47/36;A61K47/38;A61K47/48;A61P35/00;A61P35/02;C07K1/16;C07K16/28;C12N15/63 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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