发明名称 |
CARBOXYLIC ACIDS |
摘要 |
NEW MATERIAL:Syn form carboxylic acids expressed by formula I [R<1> is formula IV (Ra is amino, protected amino; X is halogen), formula V or formula VI; R<2> is carboxy or protected product of carboxy-substituted lower alkyl] and salt thereof. EXAMPLE:2-(4-Aminopyrimidine-2-yl)-2-tert. butoxycarbonylmethoxyiminoacetic acid. USE:A medicine. a synthesizing intermediate of novel 7-substituted 3-cephem-4- carboxylic acid expressed by formula VII (R<4>=R<2>) having excellent antimicrobial activity to wide pathogenic germs containing Gram-negative and Gram-positive bacteria and useful as an antibiotic. PREPARATION:A compound expressed by formula II or salt thereof is reacted with a compound expressed by formula III or salt thereof in a solvent, preferably in the presence of an organic or inorganic base normally while cooling or heating to provided the compound expressed by formula I.
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申请公布号 |
JPS63146863(A) |
申请公布日期 |
1988.06.18 |
申请号 |
JP19870290253 |
申请日期 |
1987.11.17 |
申请人 |
FUJISAWA PHARMACEUT CO LTD |
发明人 |
TAKATANI TAKAO;TAKASUGI HISASHI;MASUGI TAKASHI;YAMANAKA HIDEAKI;KAWABATA KOJI |
分类号 |
C07D209/48;A01N43/90;A61K;A61K31/545;A61K31/546;A61P31/04;C07D;C07D213/73;C07D213/75;C07D239/28;C07D239/42;C07D257/04;C07D271/06;C07D277/20;C07D277/40;C07D285/08;C07D417/12;C07D501/16;C07D501/18;C07D501/20;C07D501/22;C07D501/24;C07D501/28;C07D501/32;C07D501/34;C07D501/36;C07D513/04;C07D521/00;C07F9/6561 |
主分类号 |
C07D209/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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