NOVEL CEPHEM, PRODUCTION AND PREPARATION THEREOF

摘要

NEW MATERIAL:A compound shown by formula I [R<1> is acyl; R<2> is COOQ, COQ or SQ (Q is hydrocarbon which may be substituted); A is vinylene which may be substituted; COOR<0> is carboxyl which may be substituted] or a salt thereof. EXAMPLE:7beta-[ 2-(2-Aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido ]-3-{[N-form yl-N-(2-acetylthio-1-cyclohexenyl]amino]methyl}-3-cephem-4-carboxylic acid pivaloyloxymethyl ester. USE:An antibacterial agent Gram-positive and Gram-negative bacteria, having low toxicity. PREPARATION:A compound shown by formula II (M is alkali metal) is reacted with a compound shown by the formula R<2>-X (X and M are bonded to give eliminable group).