摘要 |
NEW MATERIAL:An aromatic derivative expressed by formula I [R<1> and R<2> are H, OH, halogen or OR<3> (R<3> is hydrocarbon group); A-B is hydrocarbon group having S or O or hydrocarbon group having at least one double bond; n is 2-4; X is C(=O)O-, OC(=O), etc.; Y is H, alkyl, etc., provided that -A- B-(CH2)n-X-Y is not formula II (R<4> is H or alkyl) when R<1> and R<2> are H]. EXAMPLE:8-(2-Naphthyl)-5,6-trans-5,6-methano-7E-octen-1-ol. USE:A treating or preventing agent for diseases, such as allergic diseases, circulatory diseases or psoriasis, and viral diseases. PREPARATION:For example, a compound expressed by formula III (R<11> and R<21> are H, halogen, etc.; R<5> is alkyl) is reacted with a compound expressed by formula IV (X' is part of X; Y' is alkyl) in the presence of a base to provide the aimed compound expressed by formula I-a (Y'' is H or alkyl). Alternatively, the above-mentioned compound expressed by formula I-a is hydrolyzed, reduced and/or deprotected to provide the aimed compound.
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