| 摘要 |
FIELD: pharmaceutics.SUBSTANCE: invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, which have antihypertensive action. In formula I X represents O or NR; groupis bonded to any carbon ring atom, different from carbon atom to which are bonded Rand R; Rrepresents hydrogen or together with Rforms =O; Rrepresents hydrogen or together with Rforms =O; Ris -Calkyl; Rand R, which are bonded to any available carbon ring atom, independently represent hydrogen or Rand Rin cases when they are bonded to same carbon atom, form =O; Ris -Calkyl, -C(O)O-C-alkyl, -C(O)O-C-alkylene-CRRR, -C(O)Calkyl, -C(O)OCcarbocycle, -C(O)aryl, -C(O)heteroaryl, where heteroaryl is unsaturated 5- or 6-member ring containing 1-4 heteroatoms selected from N, -C(O)NHCalkyl, -C(O)NH-adamantyl, -SOCalkyl, aryl or unsaturated 5- or 6-Member heteroaryl ring containing 1-4 heteroatoms selected from N, where aryl, alkyl, alkylene, carbocycle and heteroaryl are unsubstituted or substituted with 1-4 groups independently selected from -CN, halogen, -CF, -OCF, -C(O)NH, -C-alkyl, aryl, unsaturated 5-member heteroaryl ring with 1-3 nitrogen atoms, where Rand Rtogether with carbon atom to which they are bonded form Ccarbocycle or 4-8-member heterocycle containing an oxygen atom, and where Ris Calkyl.EFFECT: invention also relates to pharmaceutical compositions containing said compounds, and a method of treating hypertension.29 cl, 43 ex |
