| 发明名称 |
ANTIBODY-DRUG CONJUGATE |
| 摘要 |
As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position. |
| 申请公布号 |
US2016279259(A1) |
申请公布日期 |
2016.09.29 |
| 申请号 |
US201615180203 |
申请日期 |
2016.06.13 |
| 申请人 |
Daiichi Sankyo Company, Limited |
发明人 |
Masuda Takeshi;Naito Hiroyuki;Nakada Takashi;Yoshida Masao;Ashida Shinji;Miyazaki Hideki;Kasuya Yuji;Morita Koji;Abe Yuki;Ogitani Yusuke |
| 分类号 |
A61K47/48;A61K31/4745;C07K16/28;C07K16/30 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An antibody-drug conjugate, comprising
a linker that is connected to an antibody, represented by the following formula: -(Succinimid-3-yl-N)—CH2CH2CH2CH2CH2—C(═O)-GGFG-NH—CH2—O—CH2—C(═O)— and an antitumor compound that is connected to the linker, wherein -(Succinimid-3-yl-N)— has a structure represented by the following formula: which is connected to the antibody at position 3 thereof and is connected to a methylene group in the linker containing this structure on the nitrogen atom at position 1, and the antitumor compound is connected to the carbon atom of the carbonyl group within the —NH—CH2—O—CH2—C(═O)— moiety. |
| 地址 |
Tokyo JP |
